Cuminum cyminum L. ve Myrtus communis L. Karışım Uçucu Yağının Antikandidal Aktivitesi ve Antikandidal Mekanizmasının Belirlenmesi

C. cyminum (cumin) and M. communis (myrtle) comprise many biologically active molecules. In this study, cumin seed myrtle leaves were mixed then hydrodistilled analyzed by GC-MS. The main components of the essential oil cuminal (50.71%), 1,8 cineole (8.30%), O-cymene (7.88%), β-pinene (7.62%), α-pinene (7.16%), γ-terpinene (6.09%) α-terpinolene (2.19%). antifungal activity against albicans, parapsilosis tropicalis was investigated using spectrophotometric broth microdilution, colorimetric agar well diffusion tests. Antimicrobial mechanism EO researched TTC-dehydrogenase relative activity, protein DNA leakage analysis. While MIC values 3.29 mg mL-1 for 3.57 3.65 tropicalis, 50% cytotoxic concentration between 0.17 2.61 Candida species. inhibition yeasts in dark light conditions found as 42.1 mm on 39 exposed light, respectively. zones water, glucose, glycerol salt environment. As a result, highest IZ 26.6 albicans 26 presence 3% levels increased when yeast to EO. preserved its antimicrobial stability different environmental should contribute new research.